Ethan L Morgan
University of Sussex
Thursday 22 February 2024 5 pm Cyprus time
Targeting protein ubiquitination to improve the response to chemoradiotherapy in HPV-positive cancer
ABSTRACT
Human papillomaviruses (HPV) are a major cause of cancer worldwide, and are the primary cause of almost all cervical cancers and a growing number of cancers of the head and neck region. The viral proteins E6 and E7 are the main proteins responsible for HPV+ cancer development. Unfortunately, despite the development of vaccines for HPV infection, there is no HPV-specific treatments currently available. The most common treatment for HPV+ cancers is chemotherapy or radiotherapy. Interestingly, HPV+ cancers respond much better to these treatments than similar HPV- cancers, but the side effects can be debilitating. The reasons why HPV+ cancers respond better to current treatments are unclear. Thus, identifying why HPV+ cancers response better to these treatments may allow us to find better treatments for HPV cancer and reduce the side effects observed in HPV+ cancers.
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